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In contrast, FINO2 both indirectly inhibits the enzyme function of GPX4 and directly oxidizes iron, ultimately leading to extensive lipid peroxidation [186, 187]

Moreover, the numbers of pro-inflammatory murine Ly6C high monocytes were higher in mice fed a choline-rich diet which increased TMAO synthesis than in chow-fed control mice (Haghikia et al., 2018)