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Science, 361 (6405), 842-844

Mishanina, T

Subsequent sex comparison analysis showed that compared to that in healthy men, healthy women had higher GSTA4 methylation levels CpG1 ( p = .004, Table 5), CpG2 ( p = .024), CpG3 ( p = .042), CpG4 ( p = .041), CpG6 ( p = .038), CpG8 ( p = .035), CpG9 ( p = .02), mean methylation levels of the nine CpG sites ( p = .019)

However, this effect was reduced considerably in GSTP1-silenced cells (Figure 7C, bars 2 and 4)

Summary Keywords neurodegeneration, microbiome, neuroinflammation, protein aggregation, gut microbiota, gut metabolome, gut inflammation, Alzheimers and Parkinsons diseases Citation Padhi P, Worth C, Zenitsky G, Jin H, Sambamurti K, Anantharam V, Kanthasamy A and Kanthasamy AG (2022) Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders