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Prior to the initiation of valproic acid therapy, evaluation for UCD should be considered in the following patients: 1) those with a history of unexplained encephalopathy or coma, encephalopathy associated with a protein load, pregnancy-related or postpartum encephalopathy, unexplained mental retardation, or history of elevated plasma ammonia or glutamine

Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model

10.1038/nm.3145

Association between circadian rhythms and neurodegenerative diseases