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At the molecular level, melatonin directly binds to MMP-9, thereby inhibiting its activity and reducing ischemia/reperfusion-induced BBB hyperpermeability (148, 149)

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Unanswered Questions Regarding Weight Loss Mechanisms: Perspectives to Preclinical Research The exact mechanisms underlying the weight loss are still not clear, especially in light of the enhanced effects seen with multi-agonism, despite the large number of incretin agonists presently undergoing clinical trials and their remarkable effectiveness in managing obesity and T2DM [5, 14, 146, 147]