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This upregulation leads to increased levels of oxidized phosphatidylethanolamine, lipid peroxidation, upregulation of lipase (LIP) and ferritin heavy chain (FTH1), downregulation of GPX4, and mitochondrial outer membrane rupture

N., Trofa, D

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Insulin-like growth factor 1 receptor mediates photoreceptor neuroprotection

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However, those fatty acids need transport into the mitochondria before the body can use them for fuel