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doi: 10.1136/bmjgast-2021-000601 9 CuiWGuoMLiuDXiaoPYangCHuangHet al

They keep most of them to themselves, held in by the positively-charged protons in the nucleus, but the electrons furthest away from the nucleus (valence electrons) feel the pull less, so they can play the field more so the atom can get to its ideal numbers of valence electrons for a lot of the molecules we talk about in biochemicals (like carbon (C), nitrogen (N), oxygen (O) & sulfur (S)) this number is 8 leading to the the so-called octet rule. Hydrogen (H) is too small for that many electrons it only has a single proton, so theres no way it could keep a hold on 8

Overall, these findings clearly establish XKR8 as an essential regulator of NET formation in vitro and underscore its pivotal role in orchestrating the molecular events that drive NETosis

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Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, et al

Lebovitz et al.28 noted neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice