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Sci New York NY (2012) 336(6080):48993

However, our internal production is not infinite

In this case, organotypic brain slice cultures are considered advantageous as they allow experimental manipulation of intact CNS regions, such as demyelination of the corpus callosum through treatment with various compounds

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Ramchandani VA, Bosron WF, Li TK

But there is a real, different concern: compensation Heres where it gets more interesting, and this is the part worth understanding

After OGD treatment, the number of Ki-67-positive endothelial cells significantly decreased, while the intracellular expression levels of senescence markers P21, P53, and the DNA damage indicator -H2AX were markedly elevated (Figure 3B)