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Int J Pept Res Ther

We next describe the role of ceramides on mitochondria dysfunction assisting neurodegeneration

To validate the dependence of possible degradation on the ubiquitin-proteasome system (UPS), control samples were pretreated with the proteasomal inhibitor MG-132, the ubiquitin activating enzyme (UAE) inhibitor TAK-243 or with the neddylation inhibitor MLN4924 (blocking CRBN or VHL E3 ligase activity)

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Nevertheless, after being pre-treated with a mild dosage of H 2 O 2 and entering the stationary phase, catalase is shown to be important for peroxide resistance acquisition, suggesting its involvement in the adaptive response (Agashe and Kuzminov, 2021)