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Challenges: (1) complexity of ROS regulation: ROS is essential for normal cellular functions

10.1111/j.1365-2362.2011.02609.x 12 AtiakshinD.KostinA.ShishkinaV.BurtsevaA.BuravlevaA.VolodkinA.et al (2023a)

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Snapshot Proponents: Combats depression Helps with Alzheimers disease May reverse brain and nerve damage Improves fertility and sexual function Reduces fatigue Skeptics: May cause stomach upset May raise the risk of heart disease May suppress thyroid hormones Who Needs It

Int Urogynecol J Pelvic Floor Dysfunct 2009

Numerous important metabolic components displayed substantial changes in their mean abundance between kidneys of control and cKOt mice, including carnitine, NAD + , flavin adenine dinucleotide (FAD + ), and flavin mononucleotide (FMN) (Figure 3F)