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It has been argued, in the broad context of synaptic plasticity at excitatory synapses, that an emphasis on [Ca 2+ ] i rise as the triggering mechanism of plasticity can offer improved explanatory value over a fixation on learning rules, such as STDP (Lisman and Spruston, 2+ ] i rise is strong local activation and local spread to inactive synapses or more global influx through voltage gated channels activated by back-propogating action potentials and amplified by release from internal stores

Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with semaglutide 2.4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial Frias JP, Deenadayalan S, Erichsen L, et al

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Conserved aromatic residue confers cation selectivity in claudin-2 and claudin-10b

When that happens, you may notice more dark spots, dullness, uneven tone, and early signs of aging

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity