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Chitosan nanoparticles (CN NPs) are particularly efficient delivery vehicles for both peptides as well as for chemotherapeutic drugs that which are used in breast cancer treatment due to their good biocompatibility, susceptibility to enzymatic hydrolysis, and for their high molecular carrying capacity.11 The topo isomerase inhibitor doxorubicin (Adriamycin) is frequently used alone or in combination for the eradication of solid tumors, but a major limitation of this agent is that it also induces non-cancer cell death, thereby resulting in numerous side effects including cardiovascular toxicity

Examples include eletriptan (Relpax), rizatriptan (Maxalt), sumatriptan (Imitrex), and almotriptan (Axert) (Zomig)

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Methylation of precursor 13 may then occur using, for example, the general method outlined in Scheme 1 to obtain cation 2j