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The critical element of a HBP is a Cys-X-X-Cys-His (CXXCH) heme-binding motif within the sequence, with X representing any amino acid residue [24]

Modulation of alpha7nAchR by melatonin alleviates ischemia and reperfusion-compromised integrity of blood-brain barrier through inhibiting HMGB1-mediated microglia activation and CRTC1-mediated neuronal loss

Effects of different intensities of continuous training on vascular inflammation and oxidative stress in spontaneously hypertensive rats

elegans, blocking components of the initiation and nucleation complexes in neurons post-reproduction led to extended lifespan, whereas blocking these components in pre-reproductive animals resulted in decreased lifespan

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& Bonhoeffer, T