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However, these efforts have predominantly focused on disease-specific applications, leaving broader population-wide strategies underdeveloped

The NewcastleOttawa quality assessment scale was performed to assess the qualities of the included studies (eTable 2)

Pseudoxanthoma Elasticum an autosomal recessive subtype of hereditary spastic paraplegia caused by mutation(s) in the cyp2u1 gene, encoding cytochrome p450 2u1