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7 The inflammation causes cellular damage, and then free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), were accumulated, resulting in oxidative stress

Optimal antioxidant levels in the body have been associated with cognitive preservation, and several studies have demonstrated the neuroprotective effects of catechins, highlighting their potential as adjunctive therapy in select neurodegenerative diseases

The study found that histone acetylation (H3K14ac) in NAc was temporarily reduced after chronic social defeat stress and then continued to increase with a decrease in HDAC2 levels, as was also observed in postmortem brain tissue NAC of depressed patients

"The Multifaceted Therapeutic Role of N -acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress"

Furthermore, the mitochondria of M9a+sh EPAS1 cells maintained more well-defined cristae under hypoxia compared to M9a+shCTR and M7/8+shCTR cells (Fig

(2015) 149:48192.e7