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curculigine A (30 ) and curculigine D (31 ) and evaluated for anti-osteoporosis [57] hepatotoxicity effect on the human hepatic cell line HL-7702 and it was reported that it showed no positive effect [58]

On the one hand, they can repair the integrity of the damaged intestinal barrier and promote the enrichment and metabolic activity of protective flora (such as Akkermansia and Lactobacillus ), thereby down-regulating the low-grade chronic inflammation in the whole body and local joints through the gut-joint axis. On the other hand, they can directly inhibit the iron-dependent lipid peroxidation cascade reaction in chondrocytes (such as regulating the GPX4, NRF2 pathways and the expression levels of proteins implicated in iron metabolism) to block or delay the ferroptosis of chondrocytes

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These results suggest that acetone metabolism, which involves cytochrome P-450IIE1, may occur in the lungs and kidneys of hamsters and the nasal mucosa of rabbits

There are over 25,000 scientific studies and research articles published on Curcumin that validate its amazing antioxidant and anti-inflammatory properties