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Prospective studies revealed a U-shaped connection between dietary folate intake and the risk of breast cancer

DOI: 10.1089/thy.2018.0014

This inhibition is linked to disruptions in cellular membrane integrity and mitochondrial function, along with elevated levels of Bax, cytochrome c, cleaved caspase-9, cleaved caspase-3, Fas, p53, and cleaved caspase-8, and reduced levels of Bcl-2 and PARP (104) ( Figure 2 )

Clock protein Bmal1 and Nrf2 cooperatively control aging or oxidative response and redox homeostasis by regulating rhythmic expression of Prdx6