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APAP highly induces the expression of TGF-1 and its downstream signaling in hepatocyte necrotic regions, and blocking TGF-1 signaling by TGF receptor 1 inhibitor (GW788388) ameliorates hepatocyte inflammation and hepatocyte injury [245]

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Orthogonal protein translation using pyrrolysyl-tRNA synthetases for single- and multiple-noncanonical amino acid mutagenesis

74 The enhanced oxidant stress in the mitochondrial matrix is then mainly derived from complex I and, to a lesser degree, from complex III, 71 and the oxidant stress and injury correlate with protein adduct formation in mitochondria