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Research on people susceptible to high-altitude pulmonary edema found that patients with elevated pulmonary artery pressure in high-altitude environments had increased free radical production and transpulmonary output in pulmonary blood vessels, increased pro-inflammatory cytokine production, and decreased NO bioavailability, suggesting that HAPH is related to free radical-mediated reduction in NO bioavailability [72]

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Additional craniofacial abnormalities can include microcephaly and midfacial hypoplasia

FIGURE 7 TABLE 5 Based on preclinical and clinical studies, comparative analysis of several chitosan derivatives in cancer therapy for tumor growth suppression