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From a translational perspective, a recent study found a positive correlation of TREM2 expression levels in AT with BMI only in males and between a specific TREM2 polymorphism and BMI in female individuals 57

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Research (156) has shown that quercetin can inhibit ferroptosis in renal tubular epithelial cells by downregulating the expression of activating transcription factor 3 gene, leading to a significant increase in the expression of SLC7A11 and GPX4

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This is particularly important since BRAF V600E expression in Ink4a/Arf-deleted cells has been shown to increase the proportion of proliferative glial progenitor cells in adult mice in vivo , disrupt asymmetric cell division of OPCs, and increase OPC frequency in vitro at the expense of mature oligodendrocytes and astrocytes, respectively, without altering NSC frequency ( V600E expression and Ink4a/Arf loss than NSCs

This result of KaplanMeier analysis was consistent with the previous results that SAAM subtype C (Figs