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As a NAD + hydrolase, CD38 significantly downregulates the level of NAD +

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The USEPA and FDA define the RfD as " [a]n estimate (with uncertainty spanning perhaps an order of magnitude) of a daily oral exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime." The current official RfD for methyl mercury in the US is set at 1 ppm although EPA has historically pushed for a lower reference dose of 0.1 ppm

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