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However, non-individualized tumor vaccines do not induce immune responses against autologous tumors owing to the high heterogeneity of tumor cells

Pathogenic levels of Hcy affect inflammatory determinants such as adhesion molecules, endothelial dysfunction, oxidative stress, leukocyte adhesion, or reduced NO bioavailability [106]

112 Tajalli-NezhadS.MohammadiS.AtlasiM

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No long-term or combination-specific safety data exist

Inhibition of cyclooxygenase-2 (COX-2) with celecoxib significantly reduced PGE2, enhanced IFN- production and NO release, and increased phagocytosis of MTB by macrophages (97)