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doi: 10.2478/v10019-010-0022-z

These findings imply that LT may alleviate ovarian hormone imbalance by increasing the expression of genes involved in estrogen production (CYP19A1) and reducing the expression of genes involved in androgen synthesis (CYP17A1) and cholesterol metabolism (CYP11A1)

(Note that low total T4 was not found in the ME/CFS group.) In some ways, this syndrome is no surprise: serum thyroid hormone levels are known to drop during starvation and illness