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In a trial of patients with T2DM and a BMI of 27 kg/m2 or greater being treated with semaglutide injection for weight loss, clinically significant hypoglycemia (plasma glucose less than 54 mg/dL) was reported in 6.2% of semaglutide-treated patients versus 2.5% of placebo-treated patients

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For vitamin B12 deficiency , treatment varies according to cause and severity: Dietary deficiency : Oral cyanocobalamin supplementation (50150 micrograms daily between meals) is usually effective Pernicious anaemia or malabsorption : Intramuscular hydroxocobalamin injections are required, typically 1 mg three times weekly for two weeks, then maintenance injections every two to three months lifelong Neurological involvement : More intensive initial treatment with 1 mg hydroxocobalamin on alternate days until no further improvement [2] [18] Follow-up should include symptom review and full blood count monitoring after 1-2 months of treatment

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A 2018 review published in the Journal of Cellular Biochemistry has found that curcumin can improve platelet functions and may be beneficial for the treatment of thromboembolism and atherothrombosis ( 50 )

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