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Insulin-like growth factor-I and -II levels are associated with the progression of nonalcoholic fatty liver disease in obese children

Nucleic Acids Res 48(D1):D1104D1113 Tognacca RS, Servi L, Hernando CE, Saura-Sanchez M, Yanovsky MJ, Petrillo E, Botto JF (2019) Alternative splicing regulation during light-induced germination of seeds

doi: 10.1038/ncpgasthep0094

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Furthermore, dextran sulfate sodium or trinitrobenzenesulfonic acid-mediated colitis in mice both demonstrated a mitigation of disease when treated with a TL1A antagonist antibody, manifested as reduction in weight loss, mortality, and histologic score (6, 9)

Subcutaneous delivery suits both peptides: it gives a smooth absorption curve that fits the once-daily, pulse-timed design, and it keeps the injection itself low-volume at roughly a tenth of a millilitre