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To further investigate the systemic effect of low CoA on mitochondrial activity, we restricted Cse / mice to either 10% glucose or 10% galactose solution as their sole energy source in the drinking water after 6 days on control, no-Cys or no-Trp diets (Fig

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Activity of VT-464, a selective CYP17 lyase inhibitor, in the LNCaP prostate cancer xenograft model [abstract 64]

Gclc fl/fl mice were described previously 127 and were crossed to Mb1-Cre + expressing mice 46 to obtain the Gclc fl/fl Mb1-cre strain

Second, loss of function or mutation of Axin, GSK-3, and APC as members of the Axin complex can likewise activate the pathway and exert oncogenic effects