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The measurement of mouth opening was performed using anatomical landmarks of the maxilla and mandible, referencing either the central incisors (for dentate patients) or the alveolar ridge (for edentulous patients)

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While our mechanistic data and mouse model results are compelling, a formal statistical causal inference or randomized controlled design would be required to definitively attribute hyperprogression to the immunotherapy regimen

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We will explain the exact duration in advance