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Metformin & Vitamin B12 Deficiency: Why It Happens? In a patient taking metformin 1000 mg twice daily who has vitamin B12 deficiency, how long should vitamin B12 supplementation be continued? Which supplementation methods are effective for metformin induced vitamin B12 deficiency? DiabetesontheNet The Truth About Metformin and Vitamin B12 Metformin, one of the most frequently used medications to manage patients with diabetes, can impact the absorption of vitamin B12. A patient on Metformin with worsening neuropathy should be screened for a Metformin induced vitamin B12 deficiency: An underdiagnosed cause of diabetic neuropathy

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