Should such trials yield positive outcomes, it can be rapidly translated into clinical care to treat bipolar depression due to its availability, low cost, safety, and tolerability
Furthermore, macrophage activation by LPS is dependent on glycolysis, as inhibition of glycolysis with 2-deoxyglucose (2DG) decreases the inflammatory response, whereas inhibitors of mitochondrial respiration have no such effect, consistent with the fact that oxidative metabolism is already shut down under such conditions 38

Soeung, M, Yan, X, Zanca, C, Qian, J, Karki, M, Duan, F, Khan, H, Zhang, L, Peng, D, Williams, M, He, R, Chen, Z, Perelli, L, Chen, J, Tidwell, R, Chauhan, PK, Le, C, Lam, TA, Bhattacharya, N, Shah, R, Ho, IL, Gay, J, Carrillo, CC, Feng, N, Le, K, Gao, G, Perry, TL, Mseeh, F, Jiang, Y, Xu, Q, Zacharias, NM, Sheth, RA, Bathala, TK, Rao, P, Daw Bitar, N, Tripathi, DN, Walker, CL, Mohammad, MM, Zhang, J, Han, G, Chu, Y, Wang, R, Dang, M, Dai, E, Peng, F, Liu, Y, Jadhav, A, Lang, W, Arrechedera, C, Clemente, LC, Parra Cuentas, ER, Lu, H, Haymaker, CL, Wistuba, II, Futreal, A, Viale, A, Soth, MJ, Jones, PH, Marszalek, JR, Heffernan, TP, Draetta, G, Tannir, NM, Gao, J, Wang, L , Genovese, G, Msaouel, P
10.1097/JSA.0000000000000115 261 WesslerS.Meisner-KoberN
Genetic mutations, known as single nucleotide polymorphisms (SNPs), can occur in this gene
Washington, D.C.: Food and Drug Administration