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HSA, a protein from plasma, served as a nano carrier for ATRA and ATO due to its non-toxic, non-immunogenic, and long-circulating properties [35]

Using iPS cell-derived SJ1 knockout and SJ1 R258Q knock-in DA neurons with their isogenic controls established by CRISPR engineering, an abnormal accumulation of the calcium channel Cav1.3 and ubiquitin chains at the base of cilia, an area rich in SJ1, was observed, indicating the defective handling of ubiquitinated substrates and disrupted ciliary proteodynamics

Both have been evaluated in randomized controlled trials for acute migraine, and both carry formal recommendations in headache treatment guidelines

Heart attacks and strokes account for around 85% of the fatalities listed above

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Evaluation method Results were assessed using three methods: (1) SALT (Severity of Alopecia Tool) scoring, (2) blinded dermatologist evaluation of before/after photographs, and (3) AI-assisted assessment using ChatGPT