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This phenomenon may help explain the obesity paradox, which suggests that, even though people who are obese are at greater risk of developing heart issues, once heart disease develops, individuals with higher BMIs appear to have a lower mortality risk than people with normal BMIs

Major mechanisms include: decreased membrane transport of the drug, increased cytoplasmic detoxification, increased DNA repair, and increased tolerance to DNA damage

10.3389/fendo.2018.00035 Front

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Discussion Results from this study indicate that a co-culture system of progenitor cells and endothelial cells can create a cord network with components found in the vasculature: endothelial cells, pericytes, and basement membrane