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Diabetes Care 22:20942095 Izumino K, Sakamaki H, Ishibashi M, Takino H, Yamasaki H, Yamaguchi Y, Chikuba N, Matsumoto K, Akazawa S, Tokuyama K, et al (1997) Troglitazone ameliorates insulin resistance in patients with Werners syndrome

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To independently confirm this observation, we examined primary Atm / mouse embryonic fibroblasts (MEFs) and found that these constitutively null cells display a chronic accumulation of intracellular glutamate compared to controls (Fig