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Western blot analysis confirmed substantial reduction of SLC25A39 protein in koSLC25A39 tumors, with no notable change in SLC25A40 expression (Fig

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The isoform M2 (PKM2) is a direct target of miR-338-3p in ovarian cancer [39] and miR-139-5p in gallbladder carcinoma [40]

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AGEs not only suppress eNOS expression but also trigger oxidative stress via the MAPK/ERK pathways [77, 78] While largely inactive under normal conditions, hyperglycemia activates the polyol pathway in ECs, leading to detrimental consequences [79]