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Abstract Purposeof Review To outline the current landscape of treatments for Leber hereditary optic neuropathy (LHON) along the therapeutic delivery pipeline, exploring the mechanisms of action and evidence for these therapeutic approaches

Hypoxia-driven metabolic shifts reduce intracellular iron availability through increased lactate production, limiting Fenton reaction-mediated lipid peroxidation

Plant Mol Biol Mar 105(45):365383

ALA (alpha-linolenic acid) comes from plant sources and can be converted to EPA and DHA, though this conversion is limited in humans

The analysis was performed on a FACS Canto II cytometer and BD FACS Diva 6.1.1 software was used