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However, in a separate real-world study of 63 virologically suppressed people with HIV in Italy who switched to DOR/3TC/TDF from any prior ART regimen (mostly regimens containing an NNRTI [47%] or PI [32%] as the only anchor agent), a non-statistically significant median weight increase of 0.55 kg was observed over 12 months of follow-up [26]

This is why FDA-approved options exist for chronic weight management (for people who meet criteria)

It balances comfort (thin enough to be relatively painless) with practicality (wide enough to draw medication without excessive time)

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Drawing past your target then pushing back down also helps clear stubborn ones

It has not been FDA approved to treat obesity and is considered experimental in various countries