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for a more detailed coverage, see Anders (2008)

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Furthermore, we show that p53 phosphorylation enhances the affinity for both FOXO4 and FOXO4-DRI

Noteworthy, the relative phases between p21 and Cyclin D expression profiles were significantly altered in PER2 allele mutant mouse embryonic fibroblasts, thus indicating that alteration of p21 phase, due to mutation, might impact on cell phase locking, thereby triggering cell cycle progression

Additionally, animal studies have shown that L-Glutathione protects liver cells from oxidative stress by neutralizing free radicals and reactive oxygen species (2)