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With RSL3-induced reduction in pNPM1 levels, DNA damage sites (marked by -H2AX foci) were not repaired due to limited availability of pNPM1

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doi:10.1073/pnas.1734072100

1.1 The emerging era of RNA therapy: promises and challenges RNA therapeutics offers unique opportunities for gene expression (e.g., therapeutic proteins, antigen-based vaccines) and gene manipulation/editing (e.g., knockdown, knockout) (Damase et al., 2021