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Clinical trial data shows increased incidence of biliary disease, likely related to rapid weight loss and altered bile composition during metabolic changes

In vitro embryo culture At 18 h post insemination (hpi), the putative zygotes were washed by repeated pipetting and transferred to 25 L drops (approximately one embryo per L) of culture medium (SOF supplemented with 3 mg/mL bovine serum albumin), covered with mineral oil and cultured until Day 8 post insemination (dpi) at 38.5 C in a humidified atmosphere with 5% CO 2 , 5% O 2 and 90% N 2 in air

Wyrzykowska, A

Further research by Shi et al

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This seemingly simple mechanism has profound downstream consequences across virtually every tissue type, as actin dynamics are fundamental to cell migration, structural integrity, and signalling