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In ovarian cancer, tumor-released mesothelin, which is linked to a glycosylphosphatidylinositol (GPI) anchor, binds to MR on macrophages, driving their polarization toward the TAM phenotype, which supports tumor growth and suppresses the immune response

Cuadrado A, Manda G, Hassan A, Alcaraz MJ, Barbas C, Daiber A, et al

Having more antioxidants is a way for plants that grow at high levels with lots of UV light to protect themselves

Effective lipoxygenase inhibitors, such as CDC and zileuton, are free radical-trapping antioxidants (Yang et al., 2016)

Single-cell transcriptomic and lineage-tracing analyses suggest that resident macrophages mainly contribute to TAM pools within omental metastases and milky spots, whereas monocyte-derived macrophages dominate in ascites [20,73]

doi: 10.1038/s41598-020-78003-z 191 MortenKJBadderLKnowlesHJ