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Dermatology, 2013, 228: 34-36

The lactam bridge between Asp5 and Lys10 side chains cyclises the heptapeptide backbone and constraining it into a compact, conformationally rigid structure that stabilises the receptor-binding pharmacophore conformation required for high-affinity MC3R and MC4R engagement

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Sebaratnam D, 2025, 'Cost-utility analysis of sirolimus in the treatment of vascular malformations', in AUSTRALASIAN JOURNAL OF DERMATOLOGY , WILEY, Vol

Foundational reference: Hadley & Hruby, Discovery and development of novel melanogenic drugs (PMID 9760697)

Histopathology Biopsy of genital melanosis shows increased pigmentation of basal keratinocytes, predominantly affecting the tips of the rete to variable degrees ( Fig