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10.1002/art.23047 9

Unresolved issues were as follows: 1) crosstalk between ferroptosis and other cell death pathways (e.g., pyroptosis) in LN, 2) interplay of iron metabolism with epigenetic regulation in ferroptosis-driven autoimmunity, and 3) development of LN-specific ferroptosis inhibitors and sensitive renal biomarkers for clinical translation (225)

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In that RCT the individual upward titration of the SSRI dosage should be ascertained

Maintaining adequate B12 levels is essential for lowering homocysteine levels