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Taken together with precedent from oncology, the overall evidence indicates that Erastin has clear therapeutic potential for EMS, provided drug delivery preferentially targets lesions while sparing healthy tissue

Proteome 98, 159174

Integrating these emerging yet scattered observations, we propose a therapeutic strategy that exploits metabolic vulnerabilities to exacerbate genome instability

These results suggested that chronic hypoxia promoted the expression of Acer2 by activating HIF-2

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