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The body has fully adapted to the medication at the maintenance dose

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Thus, targeting both components should be well considered during the course of treatment

Oxidation of cholesterol to oxysterols in neurons mediates tissue injury 58,71 , whereas plasma lipoproteins, particularly low-density lipoproteins (LDLs), are oxidized by ROS and bind oxidized LDL receptor 1 (LOX1) (REF