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A amyloidosis induces neuroinflammation and affects Tau pathologya microtubule-associated protein crucial for tubulin assemblyyet recent research indicates that these may represent separate clinical processes ( Current evidence indicates that cellular impacts occur years prior to the onset of clinical symptoms, with mitochondrial failure in neurones and astrocytes acting as a primary early indicator ( While A and Tau have been the main subjects of prior study, new data emphasizes mitochondrial breakdown and the ensuing oxidative stress as early, predictable events in AD pathogenesis

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doi: 10.1097/DCR.0b013e3182741929

R.SchweitzerA.BoricicN.KnezevicD.MaticS.et al (2019)