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This distinction has important implications for therapeutic timing: anti-inflammatory interventions may be most effective if initiated early post-insult to prevent the establishment of chronic tinnitus, but may also confer benefit in established tinnitus by reducing sustained inflammatory signaling that perpetuates maladaptive plasticity

J.QinS.KimJ

An oxidation pathway, in which jasmonoyl-isoleucine is oxidized by cytochrome P450 enzymes, mainly CYP94 isoforms, to a 12-hydroxy metabolite and then further via a 12aldehydo intermediate to dicarboxy-jasmonoyl-isoleucine, together with deconjugation by amidohydrolases, is now recognized as a major route for catabolism and deactivation of the hormone, although the hydroxy intermediate can itself cause weak and sustainable expression of certain JA-responsive genes until further oxidation occurs

doi: 10.1016/s2213-8587(19)30160-3 21 LvZMWangQWanQLinJGHuMSLiuYXet al

Taavela, J

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