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13.11.2 Lung cancer Lung cancer is among the most lethal types of cancer worldwide, contributing significantly to morbidity and mortality rates (520)

The nasal route avoids gastrointestinal degradation, allowing the DSIP peptide to pass rapidly into the bloodstream

doi: 10.1016/j.redox.2025.103543 76 RongYHuangLYiKChenHLiuSZhangWet al

Research reveals that platinum-resistant HGSOC cells often exhibit suppression of Homologous Recombination (HR) repair pathways, while alternative repair mechanisms, such as Non-Homologous End Joining (NHEJ), are activated ( Single-cell RNA sequencing has revealed specific drug-resistant cell subpopulations in HGSOC that promote their growth and drug resistance through interactions with fibroblasts and endothelial cells in the tumor microenvironment ( 3.3 Apoptosis and autophagy In the apoptotic pathways of tumor cells and HGSOC cells, key proteins such as the Bcl-2 family, p53, and caspases play crucial roles ( p53, as a tumor suppressor, promotes apoptosis by inducing the expression of apoptosis-related genes, particularly in cases of DNA damage ( Autophagy plays a dual role in the drug resistance of tumor cells and HGSOC

Nanobodies as solubilization chaperones for the expression and purification of inclusion-body prone proteins

Rhizoma smilacis glabrae protects rats with gentamicin-induced kidney injury from oxidative stress-induced apoptosis by inhibiting caspase-3 activation