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In general, the instability of Env spikes is reflected in the strong antibody responses often observed to post-fusion conformations of Env in many viral infections

It has been shown that tryptophan metabolism is enhanced in COVID-19 infection, leading to a decrease in tryptophan and increased levels of kynurenine metabolites (43), which can have multiple deleterious effects on the musculoskeletal system (70)

Martn, I.S.M., Len, A.M.R., Martn, M.A.C., Vilar, E.G., Collado-Yurrita, L., de Mateo-Silleras, B., del Ro, M.P.R

Curr Opin Neurobiol 63:111121

This section moves beyond a deterministic view of SFN bioavailability to focus on the host factorsspecifically the gut microbiome and host geneticsthat act as key determinants of efficacy

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