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282 The neurological defects observed in MERRF may be related to compromised synaptic plasticity in excitatory neurons, a consequence of mitochondrial dysfunction and synaptic impairment

10.1172/JCI162720 42 DuanF

TH: Writing review & editing

Many of the diseases related to aging are associated with organic wasting caused by increased longevity, and general deterioration of the functions of the organism that leads to a lower ability to react to changes and preserve homeostasis adaptively (Lpez-Otn et al., 2013)

Injections can also cause intramuscular bleeding and orange discoloration

634,666 Tert-butylhydroquinonend and hinokitiol have also been shown to have neuroprotective effects by activating Nrf2