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Taken together, the pattern suggests that a controlled, short-lived immune activation may accompany epithelial repair, consistent with the accelerated wound closure observed in HCEpiC assays under basal, inflammatory and oxidative stress conditions ( Importantly, the interpretation of increased Th1-associated cytokines as part of a repair-associated response rather than purely deleterious inflammation is supported by emerging evidence on corneal wound healing biology ( It is also worth mentioning that cellular redox homeostasis could influence cellular pathways influencing cell fate and differentiation ( Among the strengths of the present study, the prospective, double-blind, two-period crossover design enabled within-subject assessment of clinical outcomes and tear-fluid cytokines, minimizing inter-individual variability and improving efficiency to detect reversible changes

The extract was concentrated, clarified by centrifugation and hexane added to 20% v/v

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Ongoing research conducted at Colorado State University seeks to elucidate the potential benefits of the treatment in canines, with the hope that it helps to prevent the development of diabetes in dogs