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While these findings shed light on the role of conformational flexibility in enzyme cooperativity, the molecular basis of this modulation remains unclear calling for further investigation into long-range structural dynamics

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Mutation of Tyr 180 to Ala reduced activity by ~80%, even though the side chain is far from the active site, so it is unlikely that Tyr 180 is involved in catalysis

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A similar scenario also played out on the Pacific side: low- and high-pressure systems set up in such a way as to move warm air and water from the North Pacific through the Bering Strait