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This is particularly consequential in post-mitotic organs such as the heart and brain, which possess limited regenerative capacity and are exceptionally vulnerable to proteotoxic stress

AX is a low molecular weight molecule that, according to the hapten hypothesis, does not induce an immune response unless covalently bound to a carrier, usually a protein 14 , in order to give rise to sufficiently large size 15,16

pp 11971199 Boehmerle W, Splittgerber U, Lazarus MB, Mckenzie KM, Johnston DG, Austin DJ, Ehrlich BE (2006) Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism

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Electron-withdrawing groups at positions C2, C3, C7, and C8, reduce activity, while electron-donating groups enhance it (Farmer et al., 2022)